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:: Volume 10, Issue 1 (Vol. 10, No. 1, September 2007 2007) ::
Iran South Med J 2007, 10(1): 34-39 Back to browse issues page
Efficacy of intramuscular single dose of ceftriaxon versus ten days amoxicillin for treatment of children with acute otitis media
Ali Akbar Rahbari manesh, Afshin Shirkani *1, Hooshang Akhtar Khavari, Peyman Salamaty
1- , shirkani@Razi.tums.ac.ir
Abstract:   (12533 Views)
Background: Ceftriaxone is a prolonged third-generation cephalosporin and its intramuscular single dose can provide the necessary serum level against typical pathogens of acute otitis media up to 72 hours. Methods: In a prospective, randomized clinical trial study, the efficacy of intramuscular single dose of ceftriaxone (50mg/kg/dose) was compared to 10 days amoxicillin (50mg/kg/day, divided 3 time per day) to treat acute otitis media in children. A total of 110 children aged 5 months to 12 years, with uncomplicated acute otitis media were randomly selected to receive either an oral suspension amoxicillin for 10 days or an intramuscular single dose of ceftriaxone. Results: Clinical manifestation and demographic characteristics were similar in both groups. In ceftriaxone group, 48 (88.9%) of 54 cases were recovered completely, and in amoxicilline group, the treatment was successful in 51 (99.1%) of 56 cases (p>0.05). In ceftriaxone, 2 cases and in amoxicilline group, 3 cases developed a skin rash (p>0.05). Conclusion: The efficacy of intramuscular single dose of ceftriaxone (50mg/kg) to treat uncomplicated acute otitis media in children is as effective as amoxicillin (50mg/kg/day, divided 3 times per day).
Keywords: ceftriaxone, amoxicillin, acute otitis media, antibiotic
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Type of Study: Original | Subject: General
Received: 2006/11/25 | Accepted: 2007/07/6 | Published: 2008/08/31
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Rahbari manesh A A, Shirkani A, Akhtar Khavari H, Salamaty P. Efficacy of intramuscular single dose of ceftriaxon versus ten days amoxicillin for treatment of children with acute otitis media. Iran South Med J 2007; 10 (1) :34-39
URL: http://ismj.bpums.ac.ir/article-1-5-en.html


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Volume 10, Issue 1 (Vol. 10, No. 1, September 2007 2007) Back to browse issues page
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