1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 2- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr. Iran , inabipour@gmail.com
Abstract: (5124 Views)
Background: It is not known whether infection by a specific pathogens is associated with type 2. We examined the association between chronic infection with four pathogens (Chlaydia pneumonia, Helicopacter pylori, Herpes simplex virus type 1 and cytomegalovirus) and type 2 diabetes mellitus in a general Iranian population, in the northern Persian Gulf. Materials and Methods : In a population-based study of men and women aged >25 years, a random sample of 1754 (49.2 % males, 50.8 % females) subjects were evaluated. Sera were analyzed for immunoglobulin G antibodies to C. pneumoniae, HSV-1, H. pylori, and CMV using enzyme-linked immunosorbent assay. Type 2 diabetes mellitus was defined according to criteria of American Diabetes association. Results: A total of 150 (8.6%) subjects had type 2 diabetes mellitus. In the diabetic group, 42% were seropositive for C. pneumoniae, 64.7% for H. pylori, 92.9% for HSV-1 and 94.7% for CMV. In multiple logistic regression analyses, seropositivity for C.pneumoniae (OR=0.89, CI: 0.60-1.34, P=0.602), H. pylori(OR= 0.95, CI: 0.64-1.41, P= 0.808), HSV-1(OR= 1.76, CI: 0.86-3.62, P=0.120) ,CMV(OR=0.99, CI: 0.43-2.27, P=0.982) did not show a significant independent association with type 2 diabetes mellitus after adjustment for age, sex, chronic low-grade inflammation, and cardiovascular risk factors. Conclusion: There was not a strong association between type 2 dibetes mellitus and prior infection with viral and bacterial pathogens that had been previously correlated with coronary artery disease as well as carotid atherosclerosis.
Kayedi M, Vahdat K, KalantarHormozi M, Ostovar A, Darabi H, Nabipour I. The associaty of Chlamydia pneumoniae, Helicobacter pylori Herpes simplex virus type 1 and Cytomegalovirus in the northern Persian Gulf population. Iran South Med J. 2015; 18 (1) :135-146 URL: http://ismj.bpums.ac.ir/article-1-657-en.html
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