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:: Volume 20, Number 3 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(3): 278-286 Back to browse issues page
P63 marker Expression in Usual Skin Cancers Compared With Non Tumoral Skin Lesions
Abdolhamid Esmaili *1, Mohsen Dehghani Zahedani2, Fatemeh Nili3
1- Department of Pathology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran , hamidsporteduction@gmail.com
2- Department of Pathology, School of Medicine, Hormozgan University of Medical Sciences, Hormozgan, Iran
3- Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (396 Views)

Background: Non-melanoma skin cancers including basal cell carcinoma and squamous cell carcinoma are the most common cancers in human. The aim of this study was to determine the expression of P63 marker in usual skin cancers compared with non-tomoral skin lesions.

Materials and Methods: In this cross-sectional study, sampling was performed from archival blocks of Shahid Mohammadi hospital patients during 2010-2011. 60 samples (including 30 samples of non tumoral skin lesions and 30 samples of basal cell carcinoma and squamous cell carcinoma) were studied and evaluation of p63 gene expression was done with Immunohistochemistry method. T-test and Chi-square were used for analysis of data.

Results: P63 gene were expressed in 4 cases (13.33 %) of non tumoral lesions and all tumoral lesions (100 %). In tumoral lesions, 5 cases (16.66 %) showed 1+ severity experssion, 11 cases (36.66%) 2 + severity experssion and 14 cases (46.66 %) 3+severity experssion. All 4 non tumoral lesions shoed 1+ severity experssion of P63gene.

Conclusion: The results of this study indicated that the incidence and severity of gene expression of P63 can be use for differentiation between basal cell carcinoma and squamous cell carcinoma as well as non-tumoral skin lesions. 

Keywords: Non-tumoral skin lesions, P63, basal cell carcinoma, squamous cell carcinoma
Full-Text [PDF 877 kb]   (101 Downloads)    
Type of Study: Original | Subject: Dermatology
Received: 2017/07/5 | Accepted: 2017/07/5 | Published: 2017/07/5
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Esmaili A, Dehghani Zahedani M, Nili F. P63 marker Expression in Usual Skin Cancers Compared With Non Tumoral Skin Lesions. Iran South Med J. 2017; 20 (3) :278-286
URL: http://ismj.bpums.ac.ir/article-1-879-en.html
Volume 20, Number 3 (Iranian South Medical Journal 2017) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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