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:: Volume 23, Issue 3 (Iranian South Medical Journal 2020) ::
Iran South Med J 2020, 23(3): 236-247 Back to browse issues page
Effects of Resveratrol on the Level of Urotensin II and its Receptors in the Homogenized Tissue of Diabetic Rats
Raha Rahimikian1 , Samad Akbarzadeh2, Rahimeh Rahimi1, Khalil Pourkhalili3, Marzeah Mahmoodi4, Ramin Seyedian5, Khadejeh Ghasemi6, Ali Movahed 7
1- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- Department of Physiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4- Biological statistical group, School of Health, Bushehr University of Medical Sciences, Bushehr, Iran
5- Department of Pharmacology School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
6- Pediatric Department, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
7- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , amovahed58@gmail.com
Abstract:   (463 Views)
Background: Individuals with diabetes mellitus are at serious risk of a wide range of cardiovascular complications. Urotensin 2 and its receptors play an important role in the development of cardiovascular diseeases through production of reactive oxygen species (ROS). Resveratrol is a polyphenol with antioxidant and anti-diabetic properties. The present study aimed to investigate the effects of resveratrol on urotensin 2 and its receptors in the heart tissues of diabetic rats.
Materials and Methods: In this experimental study, 48 male Wistar rats were divided into six groups (N= 8 in each group). Resveratrol was prepared in 0.5% carboxymethyl cellulose and given to the rats through oral gavage. At the end of the 60 days of treatment with resveratrol, rats’ heart tissue was collected.
Results: The weight of diabetic rats treated with 10 and 90 mg/kg bw of resveratrol significantly increased compared with the diabetic group. Furthermore, the serum levels of FBS, lipids, MDA, CK-MB and LDH decreased in the treated diabetic rats compared with the control group. Moreover, concentration of urotensin 2 and its receptors significantly decreased in the heart tissues of the diabetic rats treated with resveratrol at the dose of 10 mg/kg bw compared with the control group.
Conclusion: The current study indicated that resveratrol decreased FBS, lipids, weight, MDA and cardiac enzymes. Furthermore, resveratrol significantly reduced urotensin 2 and its receptors, which indicates its moderating effect on diabetes complications.
Keywords: Type 2 diabetes, heart disease, resveratrol, Urotensin 2, Urotensin 2 receptor
Full-Text [PDF 1031 kb]   (100 Downloads)    
Type of Study: Original | Subject: Biochemistry. Cell Biology and Genetics
Received: 2019/07/6 | Accepted: 2020/02/5 | Published: 2020/07/27
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Rahimikian R, Akbarzadeh S, Rahimi R, Pourkhalili K, Mahmoodi M, Seyedian R, et al . Effects of Resveratrol on the Level of Urotensin II and its Receptors in the Homogenized Tissue of Diabetic Rats. Iran South Med J. 2020; 23 (3) :236-247
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Volume 23, Issue 3 (Iranian South Medical Journal 2020) Back to browse issues page
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