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:: Volume 14, Issue 4 (Iranian South Medical Journal 2011) ::
Iran South Med J 2011, 14(4): 274-287 Back to browse issues page
The Potential role of marine derived food products on Alzheimer's disese and cognitive decline
Mahsan Assadi1, Reza Nemati2, Iraj Nabipour3
1- Research center for Tropical and Infections Disease, The Persian Gulf Biomedical Institute, Bushehr University of Medical Sciences, Bushehr, IRAN , msassadi16@yahoo.com
2- Department of Nuclear Medicine, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, IRAN
3- Research center for Marine-Medicine Biotechnology, The Persian Gulf Biomedical Institute, Bushehr University of Medical Sciences, Bushehr, IRAN
Abstract:   (15366 Views)

Background: Alzheimer's disese is the most frequent cause of dementia and is one of important cause of mortality and morbidity in the world. Although, there are different therapeutic options for its treatment , the results of these therapies are disappointing. Omega-3 fatty acids in marine- derived food products, affect on different mechanisms, improve cognitive function, memory.in this study, effect Omega-3 fatty acids in marine- derived food products of cognitive disorders and Alzheimer's are reviewed. Methods: The method employed in this research was a systematic bibiliographic review,in which only the double-blind placebo-controlled studies or the clinically detailed enough open-labeled studies using validated scales were retained. Results: Many studies have shown that Omega-3 fatty acids in marine- derived food products, affect by different mechanisms include decrease inflammation and oxidative stress, synaptogenesis, synaptic plasticity, and neurogenesis promotion in neuroprotection and improvement cognitive function and memory, also omega3 fatty acid could lead to a decrease in risk of Alzheimer's diseas and the other cognitive impairements. Conclusion: However, more and large clinical trials are needed to confirm the beneficial effects of omega 3 fatty acid supplementation on the management of Alzheimer's disease and cognitive decline.

Keywords: alzheimer\'s disese, cognitive decline, marine, marine products
Full-Text [PDF 254 kb]   (3864 Downloads)    
Type of Study: Original | Subject: General
Received: 2011/03/29 | Accepted: 2011/05/15 | Published: 2011/11/30
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Assadi M, Nemati R, Nabipour I. The Potential role of marine derived food products on Alzheimer's disese and cognitive decline . Iran South Med J. 2011; 14 (4) :274-287
URL: http://ismj.bpums.ac.ir/article-1-306-en.html


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Volume 14, Issue 4 (Iranian South Medical Journal 2011) Back to browse issues page
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