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:: Volume 15, Issue 1 (Iranian South Medical of Journal 2012) ::
Iran South Med J 2012, 15(1): 35-42 Back to browse issues page
A study on association of SNP-43 polymorphism in Calpain-10 gene with type 2 diabetes mellitus in the population of Eastern Azerbaijan province
Fatemeh Bahreini1, Seyed Mojtab Mohaddes Ardebili 2, Safar Farajnia3, Jalal Ghareh Sooran4, Iraj Nabipour5, Alireza Soltanian6, Akbar Ali Askarzadeh4
1- Ebn-e-Sina Institute, Tabriz, IRAN
2- School of Medicine, Tabriz University of Medical Sciences, Tabriz, IRAN , momohaddes@yahoo.com
3- Pashmineh Center, Tabriz University of Medical Sciences, Tabriz, IRAN
4- School of Medicine, Tabriz University of Medical Sciences, Tabriz, IRAN
5- The Persian Gulf Marine Biotechnology Research, The Persian Gulf Biomedical Institute, Bushehr University of Medical Sciences, Bushehr, IRAN
6- School of Health, Hamadan University of Medical Sciences, Hamadan, IRAN
Abstract:   (19015 Views)

Background: Genome – wide analysis of genetic predisposition to type 2 diabetes mellitus in different populations have yielded variable results. Calpain10, a gene that encodes a non-lysosomal cysteine protease, has been recently proposed as a type 2 diabetes susceptibility genes in the non-insulin-dependent diabetes mellitus NIDDM1 region. Aim of the study is to evaluate the relation between SNP43 and type2 diabetes. Methods: A total of 102 diabetic subjects and 100 undiabetic controls enrolled in a case-control study in Eastern Azerbaijan Azerbaijan Province. The polymerase chain reaction restriction fragment length polymorphism technique (PCR–RFLP) was applied. We use X2 test and logistic regression to analysis of data. Results: Genotypes distribution of calpain10 gene in control group were 11(11%), 86(86%) and 3(3%) with respected to A/G, G/G and A/A genotypes, respectively. In diabetic group genotypes distribution were 7(6.9%), 95(93.1%) and zero, respectively. The G allele frequency was significant difference in case and control groups. Conclusion: Since G allele is a risk factor to affect type 2 diabetes disease hence SNP43 of calpain10 gene had significant association with type 2 diabetes in Eastern Azerbaijan.

Keywords: calpain10, SNP43, type 2 diabetes, PCR-RFLP, eastern Azerbaijan
Full-Text [PDF 413 kb]   (1545 Downloads)    
Type of Study: Original | Subject: General
Received: 2012/01/16 | Accepted: 2012/01/16 | Published: 2012/01/16
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Bahreini F, Mohaddes Ardebili S M, Farajnia S, Ghareh Sooran J, Nabipour I, Soltanian A et al . A study on association of SNP-43 polymorphism in Calpain-10 gene with type 2 diabetes mellitus in the population of Eastern Azerbaijan province. Iran South Med J. 2012; 15 (1) :35-42
URL: http://ismj.bpums.ac.ir/article-1-311-en.html


Volume 15, Issue 1 (Iranian South Medical of Journal 2012) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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