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:: Volume 16, Issue 1 (Iranian South Medical Journal 2013) ::
Iran South Med J 2013, 16(1): 17-28 Back to browse issues page
Anti-cancer effect of fresh and aged garlic
Fatemeh Taji1, Mahmood Rafieian2, Reza Maghsodi2, Hedayatollah Shirzad 3
1- Department of Developmental Biology, Kharazmi University, Tehran, IRAN
2- Department of Pharmacology, Medical Plants Research Center, ShahreKord University of Medical Sceinecs, ShahreKord, IRAN
3- Department of Immunology, Medical Plants Research Center, ShahreKord University of Medical Sceinecs, ShahreKord, IRAN , shirzadeh@skums.ac.ir
Abstract:   (12392 Views)

Background: Garlic components may change due to its enzymes activity such as alliance. In this research the effect of three months old garlic on the growth of WEHI-164 fibrosarcoma cells was examined in comparison with fresh garlic in Balb/c mice. Material and Methods: In this interventional study 40 female inbred Balb/c mice were designated into 5 groups. WEHI-164 cells were injected subcutaneously in the chest of animal. Two weeks before and three weeks after injection of cancer cells, 0.2 cc of normal saline or 20 mg/kg extracts of fresh or three months old garlic was injected intraperitoneally (IP) to mice. Five days after cells’ injection until day 21, every other day, and the mean size of tumors was measured and compared with each other, using ANOVA test. The antioxidant potential of extracts and the amount of total phenolic were also measured. Results: The amount of phenolic compounds in fresh garlic extract was 12.61mg/g and in three months old garlic was 2.89 mg/g. The efficiency of fresh garlic (35.63) was further compared with three month old garlic (10.2) in prevention of oxidation (p<0.05). The mean size of tumors in groups which received fresh garlic was smaller than that of control group. This tumor size was increased by time, so that a significant difference in mention groups could be seen on days 17, 19 and 21 (p=0.001). Injection of 3-months old garlic had no effect on inhibition of growth of cancer cells compared to control group (P=0.61). Conclusion: Findings showed that garlic consumption might have important role in control and prevention of fibrosarcoma growth. But along with time the beneficial effect of garlic on cancer cells is reduced. Therefore, fresh garlic consumption is recommended.

Keywords: cancer cells, Balb/c mice, garlic, fibrosarcoma
Full-Text [PDF 331 kb]   (1764 Downloads)    
Type of Study: Original | Subject: General
Received: 2012/12/31 | Accepted: 2012/12/31 | Published: 2012/12/31
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Taji F, Rafieian M, Maghsodi R, Shirzad H. Anti-cancer effect of fresh and aged garlic . Iran South Med J. 2013; 16 (1) :17-28
URL: http://ismj.bpums.ac.ir/article-1-387-en.html

Volume 16, Issue 1 (Iranian South Medical Journal 2013) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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