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:: Volume 18, Issue 2 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(2): 421-432 Back to browse issues page
The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women
Gholamreza Pourbehi1, Mohammadreza Kalantarhormozi1, Afshin Ostovar1, Samad Akbarzadeh1, Majid Assadi2, Sina Dobaradaran3, Iraj Nabipour4, Hossean Darabi 5
1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- Systems Environmental Health, Oil, Gas and Energy Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
4- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , darabi53@yahoo.com
Abstract:   (3152 Views)

Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. Materials and Methods: A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Results: Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). Conclusion: There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms.

Keywords: IGF-1, chronic inflammation, CRP, cardiovascular diseases, metabolic syndrome
Full-Text [PDF 813 kb]   (1216 Downloads)    
Type of Study: Original | Subject: General
Received: 2015/05/3 | Accepted: 2015/05/3 | Published: 2015/05/3
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Pourbehi G, Kalantarhormozi M, Ostovar A, Akbarzadeh S, Assadi M, Dobaradaran S, et al . The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women. Iran South Med J. 2015; 18 (2) :421-432
URL: http://ismj.bpums.ac.ir/article-1-687-en.html


Volume 18, Issue 2 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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