Background: In recent years, water pipe smoking has been spread among adults especially in Asian African communities in the Middle East and Arabic countries. The aim of this study is determination of the nicotine dependence status and some related factors among women consumer in Bushehr. Material and Methods: 430 water pipe smoker women were examined in this cross-sectional study. Convenience and snowball sampling methods were used to collect data. After data collection, data were analyzed by SPSS software with using appropriate statistical tests. Results: In this study, 43.4% (N= 186) of women had moderate nicotine dependency. The overall mean and standard deviation score for nicotine dependence were 40.71±12.63. In this study, consumer’s education (p=0.004) and job (p=0.015), husband’s education (p=0.003), and job (p=0.043), history of water pipe smoking (p=0.000), intention to quit (p=0.021), and type of tobacco (p=0.003), significantly associated with nicotine dependence. Logit regression results showed that husband 's education level, age at onset of water pipe consuming and intention to quit water pipe explain nicotine dependence. Conclusion: Nicotine dependence among almost half of the consumer women was in average level and it is essential to design educational interventions for low socio - economic individuals particularly in teens and young people that this behavior has not institutionalized yet. Also for people who have no intention of quit water pipe, at first, we provide the conditions for their quitting through empowerment process and then encourage them to quit water pipe.
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