[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 4 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(4): 399-415 Back to browse issues page
The Prevalence of Hyperlipidemia Among Older People, Bushehr Elderly Health (BEH) Program
Afshin Ostovar 1, Zahra Fereidooni 2, Amin Ansari 2, MohammadJavad Haerinejad 2, Hossean Darabi 2, AliReza Raeisi 2, GholamReza Heidari 2, Bagher Larijani 3, Neda Mehrdad 3, Gita Shafiee 3, Farshad Sharifi 3, Zhaleh Shadman 3, Mohammad Reza Amini 3, Iraj Nabipour * 4
1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , Inabipour@gmail.com
Abstract:   (1095 Views)
Background: Life expectancy continues to increase and Iran’s older population grows dramatically. Old age is the strongest risk factor for developing atherosclerotic cardiovascular disease. Hence, effective lipid management can reduce the risk of developing cardiovascular disease.
Materials and Methods: Between March 2013 and October 2014, a total of 3000 men and women aged ≥ 60 years, residing in Bushehr, Iran who participated in Bushehr Elderly Health (BEH) program were evaluated for dyslipidemia. Serum lipid levels in fasting state were measured using Selectra 2 auto analyzer. The cut-offs of cardiovascular risks were derived from the National Cholesterol Education Program (NCEP) guidelines in the United States (Adult Treatment Panel [ATP] III).
Results: The prevalence rates for hypercholesterolemia (≥ 200 mg/dl), high LDL-cholesterol (≥ 130 mg/dl), low HDL-cholesterol (<40 mg/dl) and hypertriglyceridemia (≥ 150 mg/dl) were 48.0%, 42.4%, 29.6%, 35.5%, respectively. The prevalence of dyslipidemia was 87.8% in women and 80.2% in men. The prevalence rate of dyslipidemia was decreased in men with increasing age (p=0.003), however no change was observed in women. A total of 835 subjects (27.8%) used hypolipidemic drugs. The statins were the most common used hypolipidemic drugs. There were significant association between dyslipidemia and traditional cardiovascular risk factors such as diabetes mellitus, hypertension, and obesity (p<0.0001).
Conclusion: Dyslipidemia is a prevalent abnormality among Bushehr‘s older population. Therefore, interventional measures for lipid management are suggested for this population.
 
Keywords: Aging, dyslipidemia, cholesterol, triglyceride, elderly population
Full-Text [PDF 739 kb]   (297 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2017/10/28 | Accepted: 2017/10/28 | Published: 2017/10/28
References
1. Alineghad M, Matlabi H, Azizi Zeinalhajlou A. Healthy Lifestyle Status among Non- Institutionalized Older People: A Literature Review. Elderly Health Journal. 2015; 1 (2): 52-61. [Google Scholar]
2. Nabipour I. Megatrends in medicine. Bushehr: Bushehr University of Medical Sciences press, 2014; 127.
3. Kelsey Hall, Pharm.D. Cholesterol lowering therapy in the elderly. CLIPs- Current Literature and Information for Pharmacists. 2015; 19(7):1-2. (Accessed 11 Oct 2017 at https://www.samford.edu/pharmacy/files/CHIPOR/CLIPS/2015/0302Hyperlipidemia%20in%20Older%20Adults.pdf [Google Scholar]
4. Fakhrzadeh H, Sharifi F. Cardiovascular diseases in the elderly. J Gorgan Uni Med Sci. 2012; 14 (3) :1-9. [Google Scholar]
5. Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J et al; Prospective Studies Collaboration (2007). Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007; 370 (9620): 1829-39. [PubMed] [Google Scholar]
6. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014; 63(25 Pt B):2889-934.
7. Hamilton-Craig, I, Colquhoun, D, Kostner K, et al. Lipid-modifying therapy in the elderly. (2015). Vascular Health and Risk Management, 2015؛ 11, 251–263. [Google Scholar]
8. Navaei L, Mehrabi Y, Azizi F. Epidemiology of hyperlipidemia, obesity and increased blood pressure in rural areas of Tehran Province. Iran J Endocrinol Metab. 2000; 2(4): 253–262. (Persian) [Google Scholar]
9. Amiri M, Emami SR, Nabipour I, et al. Risk factors of cardiovascular diseases in Bushehr port on the basis of the WHO Monica project: The Persian Gulf Healthy Heart Project. Iran South Med J. 2004;6(2): 151–161. (Persian) [Google Scholar]
10. Mohamadi-fard N, Sadri G, Sarraf-zadegan N, et al .The prevalence of cardiovascular risk factors in rural and urban population of Isfahan & Markazi provinces. J Qazvin Univ Med Sci. 2003; 7 (2) :5-14. [Google Scholar]
11. Azizi F, Rahmani M, Emami H, et al. Cardiovascular risk factors in an Iranian urban population: Tehran lipid and glucose study (phase 1) Soz Praventivmed. 2002;47(6): 408–426. [Google Scholar]
12. Hatmi ZN, Tahvildari S, Gafarzadeh Motlag A, Sabouri Kashani A. Prevalence of coronary artery disease risk factors in Iran: A population based survey. BMC Cardiovasc Disord. 2007; 7: 32. [PubMed] [Google Scholar]
13. Tabatabaei O, Qorbani M, Samavat T, et al. Prevalence of Dyslipidemia in Iran: A Systematic Review and Meta-Analysis Study. Int J Prev Med. 2014; 5(4): 373–393. [PubMed] [Google Scholar]
14. Azizi F, Rahmani M, Emami H, et al. Cardiovascular risk factors in an Iranian urban population: Tehran lipid and glucose study (phase 1). Soz Praventivmed. 2002; 47(6): 408–26.
15. Hosseini SR, Cumming RG, Kheirkhah F, et al. Cohort profile: the Amirkola Health and Ageing Project (AHAP). Int J Epidemiol.2014; 43(5): 1393–400. [PubMed] [Google Scholar]
16. Ostovar A, Nabipour I, Larijani B, et al. Bushehr Elderly Health (BEH) Programme, phaseI (cardiovascular system). BMJOpen 2015;5(12):e009597 [Google Scholar]
17. Félix-Redondo FJ, Grau M, Fernández-Bergés D. Cholesterol and Cardiovascular Disease in the Elderly. Facts and Gaps. Aging and Disease. 2013; 4(3): 154-169 [PubMed] [Google Scholar]
18. Karimi F, Rayani M, Akbarzadeh S, et al. Prevalence of hyperlipidemias in adult population (≥19 years) of Bushehr Port; 1999. Iran South Med J. 2000; 3: 98–106. (Persian) [Google Scholar]
19. Shao H, Quan Chen L, Xu J. Treatment of dyslipidemia in the elderly. Journal of Geriatric Cardiology. 2011; 8(1): 55-64. [PubMed]
20. Schwartz JB. Primary prevention: do the very elderly require a different approach? Trends Cardiovasc Med. 2015; 25(3): 228-39. [PubMed] [Google Scholar]
21. Petersen LK, Christensen K, Kragstrup J. Lipid-lowering treatment to the end? A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds. Age Ageing. 2010; 39(6): 674–680. [PubMed] [Google Scholar]
22. Manley RW, Weisgraber KH, Farese RW. Disorders of lipid metabolism. in: Larsen PR (chief ed). Williams textbook of endocrinology. 10th ed. Philadelphia: saunders Co; 2003. 1663.
23. Kim CJ, Kim TH, Ryu WS, et al. Influence of menopause on high density lipoprotein-cholesterol and lipids. J Korean Med Sci. 2000; 15(4): 380–386. [Google Scholar]
24. Psaty BM, Anderson M, Kronmal RA, et al. The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The Cardiovascular Health Study. J Am Geriatr Soc. 2004; 52(10): 1639–1647. [PubMed] [Google Scholar]
25. Nabipour I, Amiri M, Imami SR, et al. Unhealthy lifestyles and ischaemic electrocardiographic abnormalities: the Persian Gulf Healthy Heart Study. East Mediterr Health J. 2008; 14(4):858-868. [PubMed] [Google Scholar]
26. Bahreynian M, Esmaillzadeh A. Quantity and quality of carbohydrate intake in Iran: A target for nutritional intervention. Iran Med. 2012; 15(10): 648–649. [PubMed] [Google Scholar]
27. Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the risk of coronary heart disease. Circulation. 2007; 115: 450–458. [Google Scholar]
28. Asia Pacific Cohort Studies Collaboration. Serum triglycerides as a risk factor for cardiovascular disease in the Asia-Pacific region. Circulation. 2004; 110: 2678-2686. [PubMed] [Google Scholar]
29. Melanie G, Bradley R, Christos S, et al. Intramuscular and Liver Triglycerides Are Increased in the Elderly. The Journal of Clinical Endocrinology & Metabolism 2004; 89(8):3864–3871. [PubMed] [Google Scholar]
30. Jun M, Foote C, Lv J, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet. 2010; 375(9729): 1875–1884. [PubMed] [Google Scholar]
31. Catapano AL, Reiner Z, De Backer G, et al. ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis. 2011; 217 (1): 3–46. [PubMed] [Google Scholar]
32. Ahmadi SF, Streja E, Zahmatkesh G, et al. Streja DReverse Epidemiology of Traditional Cardiovascular Risk Factors in the Geriatric Population. J Am Med Dir Assoc. 2015; 16(11):933-939. [PubMed] [Google Scholar]
33. Ghoddosi K, Ameli J, Saadat AR, et al. Dyslipidemia and its relation with smoking in Tehran. Journal of Gorgan University of Medical Sciences. 2006;8(2):55–59. [PubMed] [Google Scholar]
34. Hassinen M, Lakka TA, Komulainen P, et al. Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women. International Journal of Obesity . 2007; 31(9): 1406–1411. [PubMed] [Google Scholar]
35. Fabiana Lucena R, Tarciana Nobre de M, et al. Correlation between indicators of abdominal obesity and serum lipids in the elderly. REV ASSOC MED BRAS. 2013; 59(1):48-55. [PubMed] [Google Scholar]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ostovar A, Fereidooni Z, Ansari A, Haerinejad M, Darabi H, Raeisi A, et al . The Prevalence of Hyperlipidemia Among Older People, Bushehr Elderly Health (BEH) Program. Iran South Med J. 2017; 20 (4) :399-415
URL: http://ismj.bpums.ac.ir/article-1-892-en.html


Volume 20, Issue 4 (Iranian South Medical Journal 2017) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3767