Volume 20, Issue 5 (Iranian South Medical Journal 2017)                   Iran South Med J 2017, 20(5): 492-500 | Back to browse issues page

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Hadavand F, Vahdat K, Yazdani S, Motamed N. Levofloxacin Resistance in Blood and Urine Culture Samples in Khalij Fars Hospital of Bushehr. Iran South Med J 2017; 20 (5) :492-500
URL: http://ismj.bpums.ac.ir/article-1-901-en.html
1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Department of Infectious Diseases, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Department of Infectious Diseases, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran , k.vahdat@bpums.ac.ir
3- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Community Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract:   (4572 Views)
Background: Due to the broad-spectrum antimicrobial activity of Levofloxacin, it has been used widely around the world. Recently, levofloxacin-resistance reports have been published. In this study, we investigated resistance to levofloxacin in positive urine and blood culture samples in Persian Gulf hospital in Bushehr, Iran, during 2015-16.
Materials and Methods: In this cross-sectional study, the selection criteria included all positive urine or blood culture samples in which the amount of the isolated pathogen colony counts were more than 105. Culture samples were divided into three groups including sensitive, intermediate and resistant; based on bacterial growth around the discs. SPSS version 18.0 was used as the statistical analysis software, and a p-value of less than 0.05 was considered statistically significant.
Results: Culture samples consisted of samples of150 patients including 61 (%40.7) male and 89 (%59.3) female. Mean age of participants was 42.98 ± 29.25. Culture samples consisted of urine (% 50.7) and blood cultures (% 49.3). E.coli was the most common pathogen (% 46) and Klebsiella (% 16.7) was the second common pathogen in all cultures. Regarding the sensitivity to levofloxacin, 119 (% 79.3) samples were sensitive, 22 (% 14.7) cultures had intermediate sensitivity and 9 (%6) samples were resistant to levofloxacin. The only resistant pathogen was E.coli.
Conclusion: This study showed that Levofloxacin has a reasonably high efficiency against most of the bacterial pathogens except for the E.coli that showed some resistance. Hence, this antibiotic can still be a considered as a good choice in the treatment of most infections except E.coli
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Type of Study: Original | Subject: Microbiology and Immunology
Received: 2017/01/1 | Accepted: 2017/08/11 | Published: 2017/11/13

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