Volume 21, Issue 2 (Iranian South Medical Journal 2018)
Iran South Med J 2018, 21(2): 92-102 |
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Soltani V, Movahed A, Bargahi A, Khamisipour G, Ostovar A, Daneshi A et al . Effects of Hydroalcoholic Extract of Sargassum Oligocystum on Serum Concentration of SIRT1 and FGF21 in Streptozotocin Induced Diabetic Rat. Iran South Med J 2018; 21 (2) :92-102
URL: http://ismj.bpums.ac.ir/article-1-918-en.html
URL: http://ismj.bpums.ac.ir/article-1-918-en.html
Vida Soltani1 
, Ali Movahed2 , Afshar Bargahi2 , GholamReza Khamisipour3 , Afshin Ostovar4 , Adel Daneshi5 , Samad Akbarzadeh * 6
, Ali Movahed2 , Afshar Bargahi2 , GholamReza Khamisipour3 , Afshin Ostovar4 , Adel Daneshi5 , Samad Akbarzadeh * 6
1- Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
3- Department of Hematology, School of Paramedical, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Epidemiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
6- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran ,smdakbarzadeh@yahoo.com
2- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
3- Department of Hematology, School of Paramedical, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Epidemiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
6- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran ,
Abstract: (4651 Views)
Background: SIRT1 and FGF21 are known to regulate glucose metabolism and moderate diabetes complications. Sargassum oligocystum extract has therapeutic characteristics. This study aimed to evaluate the effects of hydroalcoholic extract of sargassum oligocystum on serum levels of SIRT1 and FGF21in diabetic rats.
Materials and methods: In this experimental study, 48 male Wistar rats were randomly assigned into six groups: the non-diabetic control, the diabetic control, the diabetic treated with 150mg/kg of the extract, the diabetic treated with 300mg/kg of extract, the diabetic treated with 450mg/kg of the extract and the diabetic treated with 100mg/kg of Metformin. After 30 days of treatment, serum levels of SIRT1 and FGF21 of rats were measured. The data was analyzed in SPSS software version 22.
Results: The extract of sargassum at the dose of 450mg/kg significantly reduced the SIRT1 serum level, but no changes were observed in the serum level of FGF21 and insulin at any of the doses. Moreover, serum glucose and insulin resistance were decreased at the doses of 300mg/kg of the extract.
Conclusion: The results of this study suggest that the algae extract did not significantly change SIRT1 and FGF21 levels in order to regulate the glucose metabolism.
Materials and methods: In this experimental study, 48 male Wistar rats were randomly assigned into six groups: the non-diabetic control, the diabetic control, the diabetic treated with 150mg/kg of the extract, the diabetic treated with 300mg/kg of extract, the diabetic treated with 450mg/kg of the extract and the diabetic treated with 100mg/kg of Metformin. After 30 days of treatment, serum levels of SIRT1 and FGF21 of rats were measured. The data was analyzed in SPSS software version 22.
Results: The extract of sargassum at the dose of 450mg/kg significantly reduced the SIRT1 serum level, but no changes were observed in the serum level of FGF21 and insulin at any of the doses. Moreover, serum glucose and insulin resistance were decreased at the doses of 300mg/kg of the extract.
Conclusion: The results of this study suggest that the algae extract did not significantly change SIRT1 and FGF21 levels in order to regulate the glucose metabolism.
Type of Study: Original |
Subject:
Biochemistry. Cell Biology and Genetics
Received: 2017/10/27 | Accepted: 2017/12/16 | Published: 2018/06/20
Received: 2017/10/27 | Accepted: 2017/12/16 | Published: 2018/06/20
References
1. Rasines-Perea Z, Teissedre P-L. Grape Polyphenols' Effects in Human Cardiovascular Diseases and Diabetes. Molecules 2017; 22(1): 68. [DOI:10.3390/molecules22010068]
2. Lin H-TV, Tsou Y-C, Chen Y-T, et al. Hwang P-A. Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes. Marine drugs 2017; 15(4): 113. [DOI:10.3390/md15040113]
3. Lechner J, O'Leary OE, Stitt AW. The pathology associated with diabetic retinopathy. Vision Research 2017; 139: 7-14. [DOI:10.1016/j.visres.2017.04.003]
4. Başaranoğlu M, Örmeci N. Nonalcoholic fatty liver disease: diagnosis, pathogenesis, and management. Turk J Gastroenterol 2014; 25: 127-32. [DOI:10.5152/tjg.2014.7675]
5. Li X. SIRT1 and energy metabolism. Acta Biochim Biophys Sin 2013; 45(1): 51-60. [DOI:10.1093/abbs/gms108]
6. Zhang X, Yeung DC, Karpisek M. et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008; 57(5): 1246-53. [DOI:10.2337/db07-1476]
7. Mu J, Pinkstaff J, Li Z, et al. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes 2012; 61(2): 505-12. [DOI:10.2337/db11-0838]
8. Fisher FM, Chui PC, Antonellis PJ, et al. Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State. Diabetes 2010; 59(11): .2781-89. [DOI:10.2337/db10-0193]
9. Chau MD, Gao J, Yang Q, et al. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway. Proceedings of the National Academy of Sciences 2010; 13; 107(28):12553-8. [DOI:10.1073/pnas.1006962107]
10. Kashi Z, Akha O, Borzouei S, et al. Insulin therapy: Side effects and their management. Journal of Clinical Excellence 2013; 1(2):1-16. (Persian)
11. Peters N, Jay N, Barraud D. et al. Metformin-associated lactic acidosis in an intensive care unit. Critical Care 2008; 26; 12(6):R149. [DOI:10.1186/cc7137]
12. Yende SR, Harle UN, Chaugule BB. et al. Therapeutic potential and health benefits of Sargassum species. Pharmacognosy reviews 2014; 8(15):1-7. [DOI:10.4103/0973-7847.125514]
13. Baleta FN, Bolaños JM, Ruma OC, et al. Phytochemicals screening and antimicrobial properties of Sargassum oligocystum and Sargassum crassifolium Extracts Journal of Medicinal Plants Studies 2017;5(1):382-7.
14. Wang PC, Zhao S, Yang BY, et al. Anti-diabetic polysaccharides from natural sources: A review. Carbohydrate polymers 2016; 148(5): 86-97. [DOI:10.1016/j.carbpol.2016.02.060]
15. Williamson G. The role of polyphenols in modern nutrition. Nutrition Bulletin 2017; 42(3): 226-35. [DOI:10.1111/nbu.12278]
16. A Stravodimos, George A, Chetter B, et al. Phytogenic polyphenols as glycogen phosphorylase inhibitors: the potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes. Current medicinal chemistry 2017; 24(4): 384-403. [DOI:10.2174/0929867324666161118122534]
17. Babu PVA, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. The Journal of nutritional biochemistry 2013; 24(11): 1777-89. [DOI:10.1016/j.jnutbio.2013.06.003]
18. Gondi M, Basha SA, Salimath PV, Rao UJ. Supplementation of Mango (Mangifera indica L.) Peel in Diet Ameliorates Cataract in Streptozotocin‐Induced Diabetic Rats. Journal of Food Biochemistry 2017; 41(1): e12300. [DOI:10.1111/jfbc.12300]
19. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18(6): 499-502. [DOI:10.1093/clinchem/18.6.499]
20. Song Y, Manson JE, Tinker L, et al. Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women the Women's Health Initiative Observational Study. Diabetes care 2007; 30(7): 1747-52. [DOI:10.2337/dc07-0358]
21. Yu WC, Chen YL, Hwang PA, et al. Fucoidan ameliorates pancreatic β‐cell death and impaired insulin synthesis in streptozotocin‐treated β cells and mice via a Sirt‐1‐dependent manner. Molecular Nutrition & Food Research 2017; 61(10): 1700136. [DOI:10.1002/mnfr.201700136]
22. Erion DM, Yonemitsu S, Nie Y, et al. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proceedings of the National PNAS 2009; 106(27): 11288-93. [DOI:10.1073/pnas.0812931106]
23. Eckardt K, Görgens SW, Raschke S, et al. Myokines in insulin resistance and type 2 diabetes. Diabetologia 2014; 57(6): 1087-99. [DOI:10.1007/s00125-014-3224-x]
24. Yang X-D, Liu CG, Tian Y-J, et al. Inhibitory effect of fucoidan on hypoglycemia in diabetes mellitus anim. Int J Clin Exp Med 2017; 10(5): 8529-34.
25. Cao Y, Jiang X, Ma H, et al. SIRT1 and insulin resistance. Journal of Diabetes and its Complications 2016; 30(1): 178-83. [DOI:10.1016/j.jdiacomp.2015.08.022]
26. Kim KT, Rioux LE, Turgeon SL. Alphaamylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry 2014; 98: 27-33 [DOI:10.1016/j.phytochem.2013.12.003]
27. Wu GJ, Shiu SM, Hsieh MC, et al. Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium. Food Hydrocolloids 2016; 53: 16-23. [DOI:10.1016/j.foodhyd.2015.01.019]
28. Motshakeri M, Ebrahimi M, Goh YM, et al. Sargassum polycystum reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes. Journal of the Science of Food and Agriculture 2013; 93(7):1772-8. [DOI:10.1002/jsfa.5971]
29. Park J, Yeom M, Hahm DH. Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation. Journal of pharmacological sciences 2016; 30: 131(2): 84-92. [DOI:10.1016/j.jphs.2016.03.007]
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