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:: Volume 21, Issue 3 (Iranian South Medical Journal 2018) ::
Iran South Med J 2018, 21(3): 197-208 Back to browse issues page
Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats
Azadeh Eskandary 1, Ahmad Ali Moazedi 2, Nastaran Zamani 3
1- Department of Biology, School of Sciences, Shahid Chamran University, Ahvaz, Iran , azade.eskandary@gmail.com
2- Department of Biology, School of Sciences, Shahid Chamran University, Ahvaz, Iran
3- Department of Biology, School of Sciences, Payamnoor University, Tehran, Iran
Abstract:   (313 Views)
Background: Previous studies have shown that statins exert neuroprotective effects. The aim of the present study was to evaluate the effects of lovastatin on learning and memory processes in adult male rats without brain damage.
Materials and Methods: In this experimental study, 35 adult male Wistar rats were randomly divided into 5 groups of 7 rats. Group 1, the control, without any injection; groups 2-4, test groups, each group received lovastatin (1, 10 and 20 mg/kg, IP daily for five days) and group 5, vehicle-treated group received the same volume of DMSO 5% as lovastatin vehicle. At the end of the treatment with lovastatin or vehicle, 8-arm radial maze and Y-maze task were used to evaluate spatial memory.
Results: The results showed that lovastatin (10, 20 mg/kg) reduced reference and working memory errors and the time elapsed in the 8-arm radial maze task in the acquisition test (P˂0.05) and further reduced these functions in retention testing (P˂0.05) compared to the control group. On the Y maze test, alternation percentage showed a significant increase in 20 mg/kg group compared to the control (P˂0.01).
Conclusion: Our results suggest that high doses of lovastatin improve spatial memory although the exact mechanism by which lovastatin affects memory is unclear and requires further investigation.
 
Keywords: Lovastatin, Learning, Memory, Rat
Full-Text [PDF 795 kb]   (108 Downloads)    
Type of Study: Original | Subject: Nervous System
Received: 2018/07/21 | Accepted: 2018/07/21 | Published: 2018/07/21
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Eskandary A, Moazedi A A, Zamani N. Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats. Iran South Med J. 2018; 21 (3) :197-208
URL: http://ismj.bpums.ac.ir/article-1-927-en.html


Volume 21, Issue 3 (Iranian South Medical Journal 2018) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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