Volume 20, Issue 4 (Iranian South Medical Journal 2017)
Iran South Med J 2017, 20(4): 317-325 |
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Jamilian M, Talaei A, Chehrei A, Rezvanfar M R, Rafei F. The Study of the Effect of Levothyroxine on Dysfunctional Uterine Bleeding (DUB) in Euthyroid Women. Iran South Med J 2017; 20 (4) :317-325
URL: http://ismj.bpums.ac.ir/article-1-884-en.html
URL: http://ismj.bpums.ac.ir/article-1-884-en.html
1- Gynecology Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
2- Endocrinology Depatment, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
3- Pathology Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
4- Statistic Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
2- Endocrinology Depatment, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
3- Pathology Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
4- Statistic Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
Abstract: (21483 Views)
Background: Hypothyroidism and hyperthyroidism are recognized as two principal causes of DUB (dysfunctional uterine bleeding) which is characterized by the menstrual cycle irregularities. Since the thyroid hormones can alter the menstrual periods; levothyroxine intake may affect the DUB in euthyroid women.
Material and Methods: This study was conducted as a randomized, double-blind, placebo-controlled clinical trial. The participants included 120 females aged between 35to 55 years old suffering DUB with non-organic origin. All of these patients had normal thyroid function, and they were taking an oral contraceptive pill (OCP). The participants were divided into two groups of 60 women. The intervention group received one tablet of levothyroxine 0.1 mg daily, while the control group received placebo for three months. At the end of three months, the data were analyzed using SPSS software version 16, and the comparison between two groups was measured using paired Student’s t-test, and covariance analysis.
Results: Our study showed that improvement rate based on the overall mix of indicators used for evaluation of menstrual cycle irregularities was 48(80%) and 51(85%) in intervention and control groups respectively. Comparision between the intervention and control groups showed no significant difference in the overall indicators of improvement before and after the intervention in these two groups (P=0.47). However, the comparison of recovery rate based on different signs of irregularities in menstrual cycles in two groups showed that recovery rate based on metrorrhagia was significantly higher in the intervention group (100%) compared to control group. Also, covariance analysis showed that the intervention group had a significantly higher recovery rate based on the duration and the interval of bleedings, and the number of pads used during menstruation, compared to control group the (F=4.352, P=0.006).
Conclusion: Levothyroxine intake can improve the menstrual cycle irregularities in euthyroid women.
Material and Methods: This study was conducted as a randomized, double-blind, placebo-controlled clinical trial. The participants included 120 females aged between 35to 55 years old suffering DUB with non-organic origin. All of these patients had normal thyroid function, and they were taking an oral contraceptive pill (OCP). The participants were divided into two groups of 60 women. The intervention group received one tablet of levothyroxine 0.1 mg daily, while the control group received placebo for three months. At the end of three months, the data were analyzed using SPSS software version 16, and the comparison between two groups was measured using paired Student’s t-test, and covariance analysis.
Results: Our study showed that improvement rate based on the overall mix of indicators used for evaluation of menstrual cycle irregularities was 48(80%) and 51(85%) in intervention and control groups respectively. Comparision between the intervention and control groups showed no significant difference in the overall indicators of improvement before and after the intervention in these two groups (P=0.47). However, the comparison of recovery rate based on different signs of irregularities in menstrual cycles in two groups showed that recovery rate based on metrorrhagia was significantly higher in the intervention group (100%) compared to control group. Also, covariance analysis showed that the intervention group had a significantly higher recovery rate based on the duration and the interval of bleedings, and the number of pads used during menstruation, compared to control group the (F=4.352, P=0.006).
Conclusion: Levothyroxine intake can improve the menstrual cycle irregularities in euthyroid women.
Type of Study: Original |
Subject:
Gynecology
Received: 2015/10/21 | Accepted: 2017/02/7 | Published: 2017/08/27
Received: 2015/10/21 | Accepted: 2017/02/7 | Published: 2017/08/27
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