Volume 29, Issue 3 (Iran South Med J 2026)
Iran South Med J 2026, 29(3): 152-164 |
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Alghasi A, Salehi Kahyeh R, Taffakh S, Farhadi kia A, Khazami A, Mafakher L, et al . Clinical Characteristics, Recurrence Patterns, and Survival of Children with Wilms Tumor: A Single-Center Retrospective Cohort Study in Ahvaz, 2017–2024. Iran South Med J 2026; 29 (3) :152-164
URL: http://ismj.bpums.ac.ir/article-1-2593-en.html
URL: http://ismj.bpums.ac.ir/article-1-2593-en.html
Arash Alghasi1 
, Roya Salehi Kahyeh *2 , Soroor Taffakh1 , Arta Farhadi kia3 , Adeleh Khazami4 , Ladan Mafakher1 , Akram Ahangarpour5 , Saeed Bitarf1 , Atefeh Rezaei1
, Roya Salehi Kahyeh *2 , Soroor Taffakh1 , Arta Farhadi kia3 , Adeleh Khazami4 , Ladan Mafakher1 , Akram Ahangarpour5 , Saeed Bitarf1 , Atefeh Rezaei1
1- Thalassemia & Hemoglobinopathy Research center, Health research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Thalassemia & Hemoglobinopathy Research center, Health research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,Salehikahish-r@ajums.ac.ir
3- Medical Point Hospital, Izmir, Turkey
4- Clinical Research Development Center, Baghaei 2 Hospital Ahvaz, Ahvaz Jundishapur of Medical Sciences, Ahvaz, Iran
5- Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Thalassemia & Hemoglobinopathy Research center, Health research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
3- Medical Point Hospital, Izmir, Turkey
4- Clinical Research Development Center, Baghaei 2 Hospital Ahvaz, Ahvaz Jundishapur of Medical Sciences, Ahvaz, Iran
5- Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract: (12 Views)
Background: Wilms tumor is the most common renal malignancy in children. Despite therapeutic advances, information on its clinical features, survival, and recurrence pattern in Iran, especially in the southern region, remains limited. This study investigated the epidemiological features and factors affecting survival and recurrence in patients with Wilms tumor in Baqaei 2 Hospital in Ahvaz, Iran.
Materials and Methods: This retrospective descriptive-analytical cohort study was conducted on medical records of 50 patients under 18 years of age with a definitive pathological diagnosis of Wilms tumor who were hospitalized and followed up in Baqaei 2 Hospital, Ahvaz, from 2017 to 2024. Demographic data, clinical symptoms, diagnostic and therapeutic methods, disease stage, survival, and recurrence were examined. Survival analysis was performed using the Kaplan–Meier method and Cox regression model.
Results: Of the 50 patients, 28 were female (56%) and 22 were male (44%), with a mean age of 4.8 ± 1.2 years. The most common clinical presentation was a painless abdominal mass (52%; 95% CI: 38.2–65.8). Based on Kaplan-Meier analysis, the 5-year overall survival rate was estimated to be 94% (95% CI: 87.2–100). The 5-year survival rate in stages I and II was 96.1% (95% CI: 91.5–100), whereas in stage IV, it was 71.4% (95% CI: 58.6–84.2). In univariate Cox regression analysis, advanced disease stage was significantly associated with reduced overall survival; HR = 3.21 (95% CI: 1.42–7.26; P = 0.004). Recurrence occurred in six patients (12%), which was descriptively more common in advanced stages; however, due to the limited number of events, an independent inferential analysis was not performed to examine factors associated with recurrence.
Conclusion:. Disease stage at diagnosis was the most important factor associated with overall survival in this cohort. Although recurrence was descriptively more frequent in advanced-stage disease, the limited number of recurrence events precluded a definitive inference regarding an independent association between disease stage and recurrence risk.
Materials and Methods: This retrospective descriptive-analytical cohort study was conducted on medical records of 50 patients under 18 years of age with a definitive pathological diagnosis of Wilms tumor who were hospitalized and followed up in Baqaei 2 Hospital, Ahvaz, from 2017 to 2024. Demographic data, clinical symptoms, diagnostic and therapeutic methods, disease stage, survival, and recurrence were examined. Survival analysis was performed using the Kaplan–Meier method and Cox regression model.
Results: Of the 50 patients, 28 were female (56%) and 22 were male (44%), with a mean age of 4.8 ± 1.2 years. The most common clinical presentation was a painless abdominal mass (52%; 95% CI: 38.2–65.8). Based on Kaplan-Meier analysis, the 5-year overall survival rate was estimated to be 94% (95% CI: 87.2–100). The 5-year survival rate in stages I and II was 96.1% (95% CI: 91.5–100), whereas in stage IV, it was 71.4% (95% CI: 58.6–84.2). In univariate Cox regression analysis, advanced disease stage was significantly associated with reduced overall survival; HR = 3.21 (95% CI: 1.42–7.26; P = 0.004). Recurrence occurred in six patients (12%), which was descriptively more common in advanced stages; however, due to the limited number of events, an independent inferential analysis was not performed to examine factors associated with recurrence.
Conclusion:. Disease stage at diagnosis was the most important factor associated with overall survival in this cohort. Although recurrence was descriptively more frequent in advanced-stage disease, the limited number of recurrence events precluded a definitive inference regarding an independent association between disease stage and recurrence risk.
Original: Original |
Subject:
Blood and cancer
Received: 2025/11/23 | Accepted: 2026/07/20 | Published: 2026/08/23
Received: 2025/11/23 | Accepted: 2026/07/20 | Published: 2026/08/23
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