[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 4 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(4): 317-325 Back to browse issues page
The Study of the Effect of Levothyroxine on Dysfunctional Uterine Bleeding (DUB) in Euthyroid Women
Mehri Jamilian 1, Afsaneh Talaei 2, Ali Chehrei * 3, Mohammad Reza Rezvanfar 2, Fatemeh Rafei 4
1- Gynecology Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
2- Endocrinology Depatment, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
3- Pathology Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
4- Statistic Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
Abstract:   (983 Views)
Background: Hypothyroidism and hyperthyroidism have been known as the most important reasons for DUB (dysfunctional uterine bleeding) that presents as menstrual irregularities. Regarding to the effects of thyroid hormones on mense, levothyroxine intake may be effective on DUB in euthyroid women.
Material and Methods: In this interventional randomized, double-blind, placebo-controlled clinical trial on 120 women aged 35-55 years old with DUB that they had no organic reasons and had normal thyroid function and they were taking oral contraceptive pill (OCP), were divided in two groups that each group included 60 women. The intervention group took one tablet of levothyroxine 0.1 mg daily and control group took placebo for three months and after 3 months, comparison between two groups were performed by using SPSS software 16 and in order to data analyzing paired t test and student t test and covariance analysis was used.
Results: Our study showed the overall recovery rate of all kinds of mense irregularities was 48(80%) and 51(85%) in intervention and control groups respectively that shows there was no difference in comparison to pretreatment (P=0/47). The comparison of recovery rate based on different kinds of mense irregularities in two groups showed that recovery rate in metrorrhagia was significantly more in intervention group (100%) than control group. Based on covariance analysis, a meaningful recovery rate in duration and interval bleeding, and the number of used pads was seen in intervention group in comparison to control group
(F=4.352, P=0.006).
Keywords: Levothyroxine, DUB, euthyroid, Women
Full-Text [PDF 587 kb]   (294 Downloads)    
Type of Study: Original | Subject: Gynecology
Received: 2017/08/27 | Accepted: 2017/08/27 | Published: 2017/08/27
1. Olive DL, Palter SF. Reproductive Physiology. Berek, Novak's Gynecologty. 15th ed. Philadelphia: Williams and Wilkins, 2012, 1012-20. [Google Scholar]
2. Kaur T, Asseja V, Sharma S. Thyroid dysfunction in dysfunctional uterine bleeding. Webmed Cent Obstet Gynecol (WMCOO) 2011; 2(9): 1-11. [Google Scholar]
3. Goldstein SR. Menorrhagia and abnormal bleeding before the menopause. Best Pract Res Clin Obtet Gynaecol 2004; 18(1): 59-69. [Google Scholar]
4. Sangeeta P, Shailja G, Jasmine K. Thyroid dysfunction in dysfunctional uterine bleeding. J Adv Res Biol Sci 2013; 5(1): 78-83.
5. Borna S, Behjati Ardakani J, Ghanbari Z, et al. Menstrual irregularities in thyroid diseases, Imam Hosptial (1999). Tehran Univ Med J 2002; 60(6): 447-52. (Persian) [Google Scholar]
6. Padmaleela K, Thomas V, Lavanya KM, et al. Thyroid disorders in dysfunctional uterine bleeding among reproductive age group women. Int J Med Pharm Sci 2013; 4(1): 41-6. [Google Scholar]
7. Maruna P. Gynecological aspects of thyroid disorders. A review. Ceska Gynekol 2006; 71(4): 332-8. [PubMed] [Google Scholar]
8. Joshi JV, Bhandarkar SD, Chadha M, et al. Menstrual irregularities and lactation failure may precede thyroid dysfunction or goitre. J Postgrad Med 1993; 39(3): 137-41. [PubMed] [Google Scholar]
9. Berent D, Zboralski K, Orzechowska A, et al. Thyroid hormones association with depression severity and clinical outcome in patients with major depressive disorder. Mol Biol Rep 2014; 41(4): 2419-25. [PubMed] [Google Scholar]
10. Kalra S, Balhara YP. Euthyroid depression: the role of thyroid hormone. Recent Pat Endocr Metab Immune Drug Discov 2014; 8(1): 38-41. [Google Scholar]
11. Attia AH, Youssef D, Hassan N, et al. Subclinical hyperthyroidism as a potential factor for dysfunctional uterine bleeding. Gynecol Endocrinol 2007; 23(2): 65-8. [PubMed] [Google Scholar]
12. Sweet MG, Schmidt-Dalton TA, Weiss PM, et al. Evaluation and management of abnormal uterine bleeding in premenopausal women. Am Fam Physician 2012; 85(1): 35-43. [PubMed] [Google Scholar]
13. Gokyildiz S, Aslan E, Beji NK, et al. The effects of menorrhagia on women's quality of life: a case-control study. ISRN Obstet Gynecol 2013; 2013; 918179. [PubMed] [Google Scholar]
14. Warner PE, Critchley HO, Lumsden MA, et al. Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. Am J Obstet Gynecol 2004; 190(5): 1216-23. [PubMed] [Google Scholar]
15. Diaz A, Laufer MR, Breech LL. Menstruation in girls and adolescents: using the menstrual cycle as a vital sign. Pediatrics 2006; 118(5): 2245-50. [PubMed] [Google Scholar]
16. Centers for Disease Control and Prevention (CDC). US. Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR Recomm Rep 2010; 59(RR-4): 1-86.
Add your comments about this article
Your username or Email:

Write the security code in the box >

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jamilian M, Talaei A, Chehrei A, Rezvanfar M R, Rafei F. The Study of the Effect of Levothyroxine on Dysfunctional Uterine Bleeding (DUB) in Euthyroid Women. Iran South Med J. 2017; 20 (4) :317-325
URL: http://ismj.bpums.ac.ir/article-1-884-en.html

Volume 20, Issue 4 (Iranian South Medical Journal 2017) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.052 seconds with 830 queries by yektaweb 3619